Vitmain B 12 Deficiency and The Role It Plays in Disease Causing DNA Mutation
نویسندگان
چکیده
A review of how vitamin B12 is used by the human body and the role it plays in DNA mutation is presented. Vitamin B12 is a compound needed for healthy function of the human body but produced downstream of the point of absorption in the digestive system, rendering it unusable. One may become B12 deficient in a variety of ways including lack of intake, disruption of B12 absorption due to disease, or disruption of cellular B12 levels by excess alcohol consumption. Deficient levels of B12 result in hypomethylation of DNA due to improper function of the methionine synthesis pathway in which B12 performs a coenzymatic function. Hypomethylation of DNA may lead to diseases including atherosclerosis, acute myocardial infarction, and a wide variety of cancers.
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تاریخ انتشار 2015